Drugs and Pharmacology Archives

Blogs related to pharmacology, drugs and therapeutics. It contains articles and blogs related to the subject of drugs, their uses and effects on the human body.

03SepSeptember 3, 2017

Paracetamol removed from markets following EMA review

European Medicines Agency (EMA) Pharmacovigilance Risk Assessment Committee (PRAC) after conducting its review trials has given its assessment that modified release Paracetamol has been removed from market due to safety hazards related to its duration of action. The main reason cited for this removal of paracetamol (acetaminophen) is the overdose of patients with such modified release preparations. Since the paracetamol overdose/poisoning can be deadly if the proper care is not administered in time, the modified release paracetamol interfered with the...

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29AugAugust 29, 2017

Can I use orlistat with warfarin

Q. Hello doctor. I am a 45 year old male. Can I use orlistat with warfarin. I have protein S deficiency and have had recurrent DVTs in the past 10 years. I used orlistat yesterday but today observed streak of blood in my stool. Should I be worried ? Ans. ORLISTAT in a low dose preparation has only recently been made available over the counter as it previously it was a prescription based medication. The blood thinner warfarin (Coumadin) exerts its effect...

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17JanJanuary 17, 2017

clarithromycin cyclosporine interaction

The use of clarithromycin in kidney transplant patients is avoided as its relatively contraindicated in view of its interaction with cyclosporine. Cytochrome P450 3A4 also known as CYP3A4 is an enzyme that metabolizes various drugs and foreign entities including toxins in the body. Cytochrome P450 enzymes system comprise of many enzymes but the two most important ones, in relation to drug-drug interactions, are CYP3A4 and CYP2D6. ...

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22OctOctober 22, 2016

HOW DOES AN ANTIBIOTIC WORK

There are three factors that determines the workings of an antibiotic The antimicrobial drug effect depends upon MINIMUM INHIBITORY CONCENTRATION It is is the lowest concentration of an antibiotic that prevents visible growth of a bacterium. OPTIMAL DOSE Normally, its known as the dose of a drug that will produce the desired effect with minimum undesirable symptoms. But in this case we will define it differently. It is the dose at which inhibitory concentration of 90 percent is achieved at the site of infection. From these two...

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